PTGER2

Across TCGA patient cohorts, PTGER2 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTGER2-associated genes across cancer lineages are Notch1, Shc_pY317, and p62 Lck ligand. Each is linked with PTGER2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTGER2-to-partner and partner-to-PTGER2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by PTGER2-low versus PTGER2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTGER2→partner) and Y-score (partner→PTGER2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.167	+3.013	.014	.018	3	2
BLCA	Shc_pY317 →	+0.228	+2.824	.038	.036	3	1
UCEC	p62 Lck ligand →	+0.396	+2.459	.011	.020	3	1
UCEC	TFRC →	+0.544	+2.459	.034	.020	2	1
UCEC	MEK1 →	+0.502	+3.584	.004	.002	1	1
UCEC	Tuberin →	+0.344	+3.584	.008	.002	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Notch1 by PTGER2 expression — UCEC

Explore this box plot interactively →