PTGER1

Across TCGA patient cohorts, PTGER1 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,148 significant associations in total. STAD shows the largest number of these associations.

The most reproducible PTGER1-associated GO terms across cancer lineages are Adenylate cyclase-activating dopamine receptor signaling pathway, Negative regulation of phospholipid metabolic process, and Regulation of collagen fibril organization. Each is linked with PTGER1 in more than 24 cancer types. Because this analysis shows association rather than direction, both PTGER1-to-partner and partner-to-PTGER1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Adenylate cyclase-activating dopamine receptor signaling pathway grouped by PTGER1-low versus PTGER1-high in LAML.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PTGER1→partner) and Y-score (partner→PTGER1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LAML	Adenylate cyclase-activating dopamine receptor signaling pathway →	-0.118	-0.758	<.001	<.001	3	25
THYM	Negative regulation of phospholipid metabolic process →	+0.070	+0.748	<.001	<.001	3	19
ESCA	Regulation of collagen fibril organization →	+0.092	+0.786	<.001	<.001	3	17
SCLC	Peptidyl-lysine hydroxylation →	+0.109	+0.842	<.001	<.001	3	17
SCLC	Protein hydroxylation →	+0.112	+1.004	.003	.003	3	17
ESCA	Collagen metabolic process →	+0.047	+0.657	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,148 associations by consensus.

Adenylate cyclase-activating dopamine receptor signaling pathway by PTGER1 expression — LAML

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