PTGER1

Across TCGA cell cohorts, PTGER1 mutation is significantly associated with the mutation status of many other genes, with 515 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PTGER1-associated genes across cancer lineages are PES1, SLC27A5, and PPP1R36. Each is linked with PTGER1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTGER1-to-partner and partner-to-PTGER1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PES1 grouped by PTGER1-low versus PTGER1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTGER1→partner) and Y-score (partner→PTGER1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PES1 →	+4.285	+4.285	.001	.001	1	2
BLOOD_Leukemia	SLC27A5 →	+3.963	+4.662	<.001	<.001	1	2
BLOOD_Leukemia	PPP1R36 →	+4.285	+4.285	.001	.001	1	2
BLOOD_Leukemia	TDRD12 →	+4.285	+4.285	.001	.001	1	2
BLOOD_Leukemia	ZDHHC20 →	+3.548	+3.845	.003	.003	1	2
BLOOD_Leukemia	KRTAP13-4 →	+5.870	+4.894	<.001	<.001	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 515 associations by consensus.

PES1 by PTGER1 expression — BLOOD_Leukemia

Explore this box plot interactively →