PTGDR2

Across TCGA cell cohorts, PTGDR2 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PTGDR2-associated genes across cancer lineages are OOSP4A, PPP1R2C, and TACR3. Each is linked with PTGDR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTGDR2-to-partner and partner-to-PTGDR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OOSP4A grouped by PTGDR2-low versus PTGDR2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTGDR2→partner) and Y-score (partner→PTGDR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OOSP4A →	+0.087	+3.793	.001	.007	3	1
BLOOD_Leukemia	PPP1R2C →	+0.230	+4.539	<.001	.007	3	1
BLOOD_Leukemia	TACR3 →	+0.035	+5.060	<.001	.001	3	1
BLOOD_Leukemia	KRTAP21-2 →	+0.115	+4.539	<.001	.007	3	1
BLOOD_Leukemia	SPEM3 →	+0.021	+4.409	<.001	.005	3	1
LUNG_NSCLC_LUAD	KRTAP20-2 →	+0.269	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

OOSP4A by PTGDR2 expression — LARGE_INTESTINE

Explore this box plot interactively →