PTF1A

Across TCGA pan-cancer cohorts, PTF1A Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated PTF1A data layer compared with 16 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher PTF1A Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated PTF1A expression acts as an unfavorable survival marker.

LUSC, PRAD, and ESCA are the cancer types where PTF1A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Median	All	0.124	0.748	<.001	30	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
ESCA	OS	Median	II,III,IV	0.216	0.702	.014	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

PTF1A–LUSC (DFS)

Open the LUSC breakdown →