PTF1A

Across TCGA patient cohorts, PTF1A protein abundance is significantly associated with the RNA expression of many other genes, with 831 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible PTF1A-associated genes across cancer lineages are LGALS2, JOSD1, and FBXO7. Each is linked with PTF1A in more than 1 cancer types. Because this analysis shows association rather than direction, both PTF1A-to-partner and partner-to-PTF1A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PTF1A versus LGALS2 in PDAC, with a Pearson correlation of 0.57.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTF1A→partner) and Y-score (partner→PTF1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	LGALS2 →	+0.910	+1.363	<.001	<.001	3	1
PDAC	JOSD1 →	-0.496	-1.484	.002	.006	3	1
PDAC	FBXO7 →	-0.430	-1.867	<.001	<.001	3	1
PDAC	TOM1 →	-0.408	-1.356	.006	.005	3	1
PDAC	PDGFB →	-0.516	-0.947	.006	.006	3	1
PDAC	MIEF1 →	-0.311	-1.619	.008	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 831 associations by consensus.

PTF1A vs LGALS2 — PDAC

Explore this scatter interactively →