PTF1A

Across TCGA cell cohorts, PTF1A RNA expression is significantly associated with the go_rna of many other GO terms, with 132 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible PTF1A-associated GO terms across cancer lineages are Pre-miRNA processing, Regulation of acute inflammatory response, and Positive regulation of microtubule polymerization. Each is linked with PTF1A in more than 2 cancer types. Because this analysis shows association rather than direction, both PTF1A-to-partner and partner-to-PTF1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Pre-miRNA processing grouped by PTF1A-low versus PTF1A-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PTF1A→partner) and Y-score (partner→PTF1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Pre-miRNA processing →	+0.072	+0.812	.008	.006	3	3
LUNG_SCLC	Regulation of acute inflammatory response →	-0.149	-0.907	<.001	.003	3	2
LUNG_SCLC	Positive regulation of microtubule polymerization →	+0.118	+0.530	<.001	.005	3	2
LUNG_SCLC	Regulation of cytosolic calcium ion concentration →	-0.052	-0.636	.003	.008	3	2
LUNG_SCLC	Regulation of syncytium formation by plasma membrane fusion →	+0.065	+0.622	.001	.009	3	2
LUNG_SCLC	Regulation of proteasomal protein catabolic process →	+0.051	+0.848	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 132 associations by consensus.

Pre-miRNA processing by PTF1A expression — LUNG_SCLC

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