PTF1A

Across TCGA cell cohorts, PTF1A mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PTF1A-associated genes across cancer lineages are CFHR2, FAM47A, and KRTAP4-6. Each is linked with PTF1A in more than 1 cancer types. Because this analysis shows association rather than direction, both PTF1A-to-partner and partner-to-PTF1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CFHR2 grouped by PTF1A-low versus PTF1A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTF1A→partner) and Y-score (partner→PTF1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CFHR2 →	+0.046	+4.437	<.001	.004	3	1
BLOOD_Leukemia	FAM47A →	+0.041	+4.922	<.001	.009	3	1
BLOOD_Leukemia	KRTAP4-6 →	+0.024	+5.201	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

CFHR2 by PTF1A expression — LARGE_INTESTINE

Explore this box plot interactively →