PTF1A

Across TCGA cell cohorts, PTF1A mutation is significantly associated with the mutation status of many other genes, with 1,227 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTF1A-associated genes across cancer lineages are NIPAL4, FBH1, and ZNF107. Each is linked with PTF1A in more than 2 cancer types. Because this analysis shows association rather than direction, both PTF1A-to-partner and partner-to-PTF1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NIPAL4 grouped by PTF1A-low versus PTF1A-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTF1A→partner) and Y-score (partner→PTF1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	NIPAL4 →	+4.502	+5.066	.007	.007	1	3
BLOOD_Leukemia	FBH1 →	+4.000	+5.050	.008	.008	1	3
BLOOD_Leukemia	ZNF107 →	+4.321	+5.285	.005	.005	1	3
LUNG_SCLC	TSGA10 →	+5.502	+5.502	.003	.003	1	3
LARGE_INTESTINE	ITGA1 →	+2.422	+4.050	.004	.004	1	3
BLOOD_Leukemia	AMER2 →	+4.321	+5.285	.005	.005	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,227 associations by consensus.

NIPAL4 by PTF1A expression — LUNG_SCLC

Explore this box plot interactively →