PTDSS1

Across TCGA pan-cancer cohorts, PTDSS1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PTDSS1 data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PTDSS1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PTDSS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, COAD, and GBM are the cancer types where PTDSS1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	II,III,IV	1.000	0.847	.004	23	view →
COAD	DFS	Median	III,IV	0.826	1.000	.023	12	view →
GBM	DFS	Quartile	All	0.548	0.868	.027	8	view →
CCRCC	DFS	Quartile	II,III,IV	0.765	1.000	.013	7	view →
PDAC	DFS	Quartile	All	0.633	0.791	.014	5	view →
LUAD	OS	Tertile	III,IV	0.747	0.257	.032	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PTDSS1–HNSC (DFS)

Open the HNSC breakdown →