PTDSS1

Across TCGA patient cohorts, PTDSS1 mutation is significantly associated with the RNA expression of many other genes, with 2,553 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTDSS1-associated genes across cancer lineages are MIR4644, PEBP1P1, and KCTD14. Each is linked with PTDSS1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PTDSS1-to-partner and partner-to-PTDSS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4644 grouped by PTDSS1-low versus PTDSS1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTDSS1→partner) and Y-score (partner→PTDSS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR4644 →	+0.517	+3.059	.004	.005	3	3
CESC	PEBP1P1 →	+0.090	+4.276	<.001	.008	3	2
UCEC	KCTD14 →	+1.151	+2.839	<.001	<.001	3	2
UCEC	PANK4 →	+0.379	+2.332	.001	<.001	3	2
UCEC	EYA3 →	+0.523	+2.923	<.001	<.001	3	2
UCEC	RNF166 →	+0.456	+3.711	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,553 associations by consensus.

MIR4644 by PTDSS1 expression — SKCM

Explore this box plot interactively →