PTDSS1

Across TCGA patient cohorts, PTDSS1 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTDSS1-associated genes across cancer lineages are ASNS, FoxM1, and Annexin_VII. Each is linked with PTDSS1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PTDSS1-to-partner and partner-to-PTDSS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by PTDSS1-low versus PTDSS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTDSS1→partner) and Y-score (partner→PTDSS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.535	+2.222	<.001	.010	3	3
UCEC	FoxM1 →	+0.309	+2.009	.002	.017	3	2
UCEC	Annexin_VII →	-0.193	-3.169	<.001	<.001	3	2
UCEC	Shc_pY317 →	-0.175	-2.000	.003	.010	3	2
UCEC	C-Raf →	+0.208	+2.700	<.001	.006	3	2
UCEC	14-3-3_beta →	-0.130	-1.986	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

ASNS by PTDSS1 expression — UCEC

Explore this box plot interactively →