PTDSS1

Across TCGA cell cohorts, PTDSS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,957 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PTDSS1-associated GO terms across cancer lineages are Regulation of DNA-templated DNA replication initiation, DNA-templated DNA replication, and Positive regulation of chromosome separation. Each is linked with PTDSS1 in more than 12 cancer types. Because this analysis shows association rather than direction, both PTDSS1-to-partner and partner-to-PTDSS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of DNA-templated DNA replication initiation grouped by PTDSS1-low versus PTDSS1-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PTDSS1→partner) and Y-score (partner→PTDSS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Regulation of DNA-templated DNA replication initiation →	+0.163	+1.223	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	DNA-templated DNA replication →	+0.116	+1.375	<.001	<.001	3	13
BREAST	Positive regulation of chromosome separation →	+0.139	+0.963	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	DNA integrity checkpoint signaling →	+0.076	+1.156	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	DNA replication →	+0.107	+1.375	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Double-strand break repair →	+0.071	+0.976	<.001	.002	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,957 associations by consensus.

Regulation of DNA-templated DNA replication initiation by PTDSS1 expression — PANCREAS

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