PTDSS1

Across TCGA cell cohorts, PTDSS1 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PTDSS1-associated genes across cancer lineages are MYPN, STRA8, and DBX2. Each is linked with PTDSS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTDSS1-to-partner and partner-to-PTDSS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYPN grouped by PTDSS1-low versus PTDSS1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTDSS1→partner) and Y-score (partner→PTDSS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MYPN →	+0.026	+4.152	<.001	.009	3	1
LUNG_NSCLC_LUAD	STRA8 →	+0.367	+3.959	<.001	.001	3	1
LUNG_NSCLC_LUAD	DBX2 →	+0.020	+5.442	<.001	<.001	3	1
LUNG_NSCLC_LUAD	IFNA2 →	+0.018	+3.604	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

MYPN by PTDSS1 expression — BLOOD_Leukemia

Explore this box plot interactively →