PTCRA

Across TCGA cell cohorts, PTCRA RNA expression is significantly associated with the go_rna of many other GO terms, with 2,347 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible PTCRA-associated GO terms across cancer lineages are Negative regulation of endopeptidase activity, Collagen fibril organization, and Positive regulation of intestinal cholesterol absorption. Each is linked with PTCRA in more than 3 cancer types. Because this analysis shows association rather than direction, both PTCRA-to-partner and partner-to-PTCRA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of endopeptidase activity grouped by PTCRA-low versus PTCRA-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PTCRA→partner) and Y-score (partner→PTCRA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Negative regulation of endopeptidase activity →	-0.933	-0.360	<.001	<.001	3	4
BLOOD_Lymphoma	Collagen fibril organization →	-0.082	-0.258	<.001	<.001	3	4
BLOOD_Lymphoma	Positive regulation of intestinal cholesterol absorption →	-0.149	-0.287	.002	.001	3	4
BLOOD_Leukemia	Granzyme-mediated programmed cell death signaling pathway →	-0.100	-1.845	.002	.001	3	4
BLOOD_Leukemia	Lactate transport →	-0.113	-1.037	<.001	.001	3	4
SKIN	Establishment of apical/basal cell polarity →	-0.080	-0.936	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,347 associations by consensus.

Negative regulation of endopeptidase activity by PTCRA expression — BLOOD_Lymphoma

Explore this box plot interactively →