PTCRA

Across TCGA cell cohorts, PTCRA mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PTCRA-associated genes across cancer lineages are IQCF5, OR12D3, and SLC10A2. Each is linked with PTCRA in more than 1 cancer types. Because this analysis shows association rather than direction, both PTCRA-to-partner and partner-to-PTCRA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IQCF5 grouped by PTCRA-low versus PTCRA-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTCRA→partner) and Y-score (partner→PTCRA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IQCF5 →	+0.108	+5.786	<.001	<.001	3	2
LUNG_NSCLC_LUAD	OR12D3 →	+0.044	+5.813	<.001	<.001	3	1
LUNG_NSCLC_LUAD	SLC10A2 →	+0.031	+4.371	<.001	.005	3	1
LUNG_NSCLC_LUAD	GFRA4 →	+0.027	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	H2BC1 →	+0.753	+4.544	<.001	.003	3	1
LUNG_NSCLC_LUAD	TOPAZ1 →	+0.009	+4.662	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

IQCF5 by PTCRA expression — BLOOD_Leukemia

Explore this box plot interactively →