PTCHD3

Across TCGA patient cohorts, PTCHD3 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,399 significant associations in total. STAD shows the largest number of these associations.

The most reproducible PTCHD3-associated GO terms across cancer lineages are Response to endoplasmic reticulum stress, Nuclear-transcribed mRNA catabolic process, and Negative regulation of transferase activity. Each is linked with PTCHD3 in more than 17 cancer types. Because this analysis shows association rather than direction, both PTCHD3-to-partner and partner-to-PTCHD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to endoplasmic reticulum stress grouped by PTCHD3-low versus PTCHD3-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PTCHD3→partner) and Y-score (partner→PTCHD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Response to endoplasmic reticulum stress →	+0.070	+0.200	<.001	<.001	3	18
ESCA	Nuclear-transcribed mRNA catabolic process →	+0.082	+0.391	<.001	<.001	3	16
STAD	Negative regulation of transferase activity →	+0.065	+0.208	<.001	<.001	3	16
ESCA	RNA localization →	+0.086	+0.269	<.001	<.001	3	16
STAD	Endoplasmic reticulum to Golgi vesicle-mediated transport →	+0.070	+0.187	<.001	<.001	3	16
STAD	Regulation of RNA splicing →	+0.076	+0.192	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,399 associations by consensus.

Response to endoplasmic reticulum stress by PTCHD3 expression — STAD

Explore this box plot interactively →