PTCHD3

Across TCGA cell cohorts, PTCHD3 mutation is significantly associated with the RNA expression of many other genes, with 131 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTCHD3-associated genes across cancer lineages are KRTAP17-1, OR6A2, and COX4I2. Each is linked with PTCHD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTCHD3-to-partner and partner-to-PTCHD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP17-1 grouped by PTCHD3-low versus PTCHD3-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTCHD3→partner) and Y-score (partner→PTCHD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	KRTAP17-1 →	+0.011	+4.369	<.001	.008	3	2
CNS	OR6A2 →	+0.039	+3.573	.001	.007	3	2
LUNG_NSCLC_LUAD	COX4I2 →	+0.050	+3.813	<.001	.001	3	2
LUNG_NSCLC_LUAD	MT1HL1 →	+0.074	+3.944	<.001	.006	3	2
LUNG_NSCLC_LUAD	TEX49 →	+0.092	+3.374	<.001	.002	3	2
BLOOD_Leukemia	PIWIL1 →	+0.049	+4.044	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 131 associations by consensus.

KRTAP17-1 by PTCHD3 expression — SOFT_TISSUE

Explore this box plot interactively →