PTCHD1

Across TCGA patient cohorts, PTCHD1 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTCHD1-associated genes across cancer lineages are Caspase-7-cleavedD198, ASNS, and PDCD4. Each is linked with PTCHD1 in more than 5 cancer types. Because this analysis shows association rather than direction, both PTCHD1-to-partner and partner-to-PTCHD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PTCHD1-low versus PTCHD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTCHD1→partner) and Y-score (partner→PTCHD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.529	+1.543	.001	.004	3	6
SKCM	ASNS →	+0.407	+3.000	.030	.035	3	3
SKCM	PDCD4 →	-0.365	-3.000	.036	.035	3	2
SKCM	YAP_pS127 →	-0.434	-3.906	.005	<.001	3	2
UCEC	eIF4E →	+0.141	+1.398	.018	.004	3	2
UCEC	ERK2 →	+0.132	+1.502	.015	.025	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Caspase-7-cleavedD198 by PTCHD1 expression — UCEC

Explore this box plot interactively →