PTCHD1

Across TCGA cell cohorts, PTCHD1 RNA expression is significantly associated with the go_rna of many other GO terms, with 585 significant associations in total. CNS shows the largest number of these associations.

The most reproducible PTCHD1-associated GO terms across cancer lineages are Establishment of protein localization to organelle, Nuclear RNA surveillance, and Host-mediated perturbation of viral transcription. Each is linked with PTCHD1 in more than 4 cancer types. Because this analysis shows association rather than direction, both PTCHD1-to-partner and partner-to-PTCHD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Establishment of protein localization to organelle grouped by PTCHD1-low versus PTCHD1-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PTCHD1→partner) and Y-score (partner→PTCHD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Establishment of protein localization to organelle →	+0.049	+0.122	<.001	<.001	3	5
OESOPHAGUS	Nuclear RNA surveillance →	+0.090	+0.133	<.001	.002	3	5
CNS	Host-mediated perturbation of viral transcription →	+0.061	+0.409	<.001	.002	3	5
CNS	RNA destabilization →	+0.036	+0.525	<.001	.008	3	5
CNS	mRNA destabilization →	+0.029	+0.442	.005	.004	3	5
CNS	Negative regulation of RNA catabolic process →	+0.029	+0.568	.004	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 585 associations by consensus.

Establishment of protein localization to organelle by PTCHD1 expression — OVARY

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