PTCHD1

Across TCGA cell cohorts, PTCHD1 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PTCHD1-associated genes across cancer lineages are DMRTB1, GJD2, and TRARG1. Each is linked with PTCHD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTCHD1-to-partner and partner-to-PTCHD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DMRTB1 grouped by PTCHD1-low versus PTCHD1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTCHD1→partner) and Y-score (partner→PTCHD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DMRTB1 →	+0.006	+4.887	<.001	.009	3	1
LARGE_INTESTINE	GJD2 →	+0.003	+4.022	<.001	.006	3	1
SKIN	TRARG1 →	+0.008	+3.196	<.001	.007	3	1
SKIN	GLRA4 →	+0.023	+3.882	<.001	.001	3	1
SKIN	EGFL6 →	+0.222	+3.453	.009	.009	3	1
BLOOD_Leukemia	DPT →	+1.503	+3.769	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

DMRTB1 by PTCHD1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →