PTCHD1

Across TCGA cell cohorts, PTCHD1 mutation is significantly associated with the mutation status of many other genes, with 2,302 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTCHD1-associated genes across cancer lineages are WDR17, WNK3, and SYNRG. Each is linked with PTCHD1 in more than 4 cancer types. Because this analysis shows association rather than direction, both PTCHD1-to-partner and partner-to-PTCHD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WDR17 grouped by PTCHD1-low versus PTCHD1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTCHD1→partner) and Y-score (partner→PTCHD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	WDR17 →	+2.870	+3.347	.009	.009	1	5
BLOOD_Leukemia	WNK3 →	+5.870	+4.894	<.001	<.001	1	5
LUNG_NSCLC_LUAD	SYNRG →	+4.772	+5.339	.004	.004	1	5
BLOOD_Leukemia	PRRC2B →	+2.285	+3.364	.006	.006	1	4
SKIN	BICD1 →	+4.548	+3.169	.004	.004	1	4
SKIN	ABCC8 →	+3.378	+2.947	.002	.002	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,302 associations by consensus.

WDR17 by PTCHD1 expression — BLOOD_Leukemia

Explore this box plot interactively →