PTCH2

Across TCGA patient cohorts, PTCH2 RNA expression is significantly associated with the RNA expression of many other genes, with 18,217 significant associations in total. UVM shows the largest number of these associations.

The most reproducible PTCH2-associated genes across cancer lineages are GIGYF1, SIN3B, and SKI. Each is linked with PTCH2 in more than 30 cancer types. Because this analysis shows association rather than direction, both PTCH2-to-partner and partner-to-PTCH2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PTCH2 versus GIGYF1 in SCLC, with a Pearson correlation of 0.75.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTCH2→partner) and Y-score (partner→PTCH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	GIGYF1 →	+1.318	+1.245	<.001	<.001	3	31
ACC	SIN3B →	+1.248	+0.585	<.001	.004	3	30
KICH	SKI →	+1.028	+0.373	<.001	<.001	3	30
ACC	ZNF783 →	+1.155	+0.842	<.001	<.001	3	30
MESO	GLI1 →	+2.182	+1.893	<.001	<.001	3	30
KIRC	CROCCP3 →	+0.862	+0.677	<.001	<.001	3	30

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,217 associations by consensus.

PTCH2 vs GIGYF1 — SCLC

Explore this scatter interactively →