PTCH2

Across TCGA patient cohorts, PTCH2 mutation is significantly associated with the RNA expression of many other genes, with 2,670 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTCH2-associated genes across cancer lineages are ZFYVE19, GINS2, and MYPOP. Each is linked with PTCH2 in more than 3 cancer types. Because this analysis shows association rather than direction, both PTCH2-to-partner and partner-to-PTCH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZFYVE19 grouped by PTCH2-low versus PTCH2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTCH2→partner) and Y-score (partner→PTCH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZFYVE19 →	+0.332	+1.872	.001	.004	3	4
STAD	GINS2 →	+0.863	+3.647	.001	.001	3	4
UCEC	MYPOP →	+0.342	+1.879	<.001	<.001	3	3
SKCM	ATAD3A →	+0.453	+2.028	.003	.005	3	3
SKCM	GPATCH3 →	+0.294	+1.546	.004	.009	3	3
SKCM	SNRNP25 →	+0.324	+2.434	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,670 associations by consensus.

ZFYVE19 by PTCH2 expression — UCEC

Explore this box plot interactively →