PTCH2

Across TCGA patient cohorts, PTCH2 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTCH2-associated genes across cancer lineages are FoxM1, 4E-BP1_pS65, and Bap1-c-4. Each is linked with PTCH2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PTCH2-to-partner and partner-to-PTCH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by PTCH2-low versus PTCH2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTCH2→partner) and Y-score (partner→PTCH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	FoxM1 →	+0.248	+2.459	.001	.018	3	3
SKCM	4E-BP1_pS65 →	+0.185	+2.000	.017	.009	3	3
STAD	Bap1-c-4 →	+0.305	+3.000	.046	.034	3	2
UCEC	eEF2 →	+0.342	+1.514	.004	.015	3	2
UCEC	SCD →	-0.078	-1.234	.038	.045	3	2
UCEC	Shc_pY317 →	-0.116	-1.700	.024	.042	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

FoxM1 by PTCH2 expression — SKCM

Explore this box plot interactively →