PTCH2

Across TCGA cell cohorts, PTCH2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,587 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTCH2-associated GO terms across cancer lineages are Subtelomeric heterochromatin formation, Positive regulation of monoatomic ion transport, and Negative regulation of gene expression, epigenetic. Each is linked with PTCH2 in more than 13 cancer types. Because this analysis shows association rather than direction, both PTCH2-to-partner and partner-to-PTCH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Subtelomeric heterochromatin formation grouped by PTCH2-low versus PTCH2-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PTCH2→partner) and Y-score (partner→PTCH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Subtelomeric heterochromatin formation →	+0.116	+0.609	.002	.005	3	14
PANCREAS	Positive regulation of monoatomic ion transport →	-0.075	-0.227	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Negative regulation of gene expression, epigenetic →	+0.062	+0.240	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	mRNA splice site recognition →	+0.149	+0.235	<.001	<.001	3	14
STOMACH	RNA catabolic process →	+0.062	+0.670	.006	.004	3	14
OESOPHAGUS	Nucleic acid catabolic process →	+0.055	+0.311	.003	.001	2	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,587 associations by consensus.

Subtelomeric heterochromatin formation by PTCH2 expression — STOMACH

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