PTCH2

Across TCGA cell cohorts, PTCH2 mutation is significantly associated with the RNA expression of many other genes, with 680 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTCH2-associated genes across cancer lineages are HIPK4, ALOXE3, and USP17L17. Each is linked with PTCH2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTCH2-to-partner and partner-to-PTCH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HIPK4 grouped by PTCH2-low versus PTCH2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTCH2→partner) and Y-score (partner→PTCH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HIPK4 →	+0.053	+3.257	<.001	.009	3	2
BLOOD_Leukemia	ALOXE3 →	+0.243	+3.554	<.001	.007	3	2
BLOOD_Leukemia	USP17L17 →	+0.002	+3.984	<.001	.006	3	2
BLOOD_Leukemia	ELOA3CP →	+0.103	+3.526	.001	.008	3	2
LUNG_NSCLC_LUAD	MS4A10 →	+0.499	+3.544	<.001	.009	3	2
LARGE_INTESTINE	GCAT →	+0.973	+2.364	.004	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 680 associations by consensus.

HIPK4 by PTCH2 expression — BLOOD_Leukemia

Explore this box plot interactively →