Across TCGA patient cohorts, PTCH1 protein abundance is significantly associated with the RNA expression of many other genes, with 1,031 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PTCH1-associated genes across cancer lineages are RABGGTA, PIGU, and RBFA. Each is linked with PTCH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTCH1-to-partner and partner-to-PTCH1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTCH1→partner) and Y-score (partner→PTCH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RABGGTA →	-0.296	-0.736	<.001	<.001	3	1
GBM	PIGU →	-0.546	-1.042	<.001	.006	3	1
GBM	RBFA →	-0.489	-0.619	.005	.004	3	1
GBM	UBL4A →	-0.423	-0.648	.008	.003	3	1
GBM	PDGFRL →	+0.610	+0.610	.004	.004	3	1
GBM	DCPS →	-0.372	-0.857	.007	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,031 associations by consensus.

Exploration

PTCH1 survival (RNA) · tumor vs normal (RNA) · all PTCH1 data types