Across TCGA patient cohorts, PTCH1 mutation is significantly associated with the total protein of many other genes, with 67 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTCH1-associated genes across cancer lineages are PDCD4, 4E-BP1, and Cyclin-B1. Each is linked with PTCH1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PTCH1-to-partner and partner-to-PTCH1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTCH1→partner) and Y-score (partner→PTCH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.290	-1.459	.012	.009	3	4
STAD	4E-BP1 →	+0.374	+2.321	.005	.034	3	3
UCEC	Cyclin-B1 →	+0.549	+2.115	<.001	<.001	3	3
UCEC	eIF4E →	+0.242	+2.000	<.001	<.001	3	3
COAD	GAPDH →	+0.798	+2.467	<.001	.011	3	3
COAD	PCNA →	+0.287	+2.467	.007	.011	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

Exploration

PTCH1 survival (RNA) · tumor vs normal (RNA) · all PTCH1 data types