Across TCGA cell cohorts, PTCH1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,916 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible PTCH1-associated GO terms across cancer lineages are Neural tube patterning, Mitotic chromosome condensation, and Regulation of nucleotide-excision repair. Each is linked with PTCH1 in more than 13 cancer types. Because this analysis shows association rather than direction, both PTCH1-to-partner and partner-to-PTCH1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PTCH1→partner) and Y-score (partner→PTCH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Neural tube patterning →	+0.158	+1.741	.003	.004	3	13
BREAST	Mitotic chromosome condensation →	+0.111	+1.133	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Regulation of nucleotide-excision repair →	+0.116	+1.462	<.001	<.001	3	12
STOMACH	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.140	+1.205	.008	.005	1	14
KIDNEY	Negative regulation of smoothened signaling pathway →	+0.070	+1.095	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Positive regulation of DNA metabolic process →	+0.052	+0.994	<.001	.002	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,916 associations by consensus.

Exploration

PTCH1 survival (RNA) · tumor vs normal (RNA) · all PTCH1 data types