Across TCGA cell cohorts, PTCH1 mutation is significantly associated with the RNA expression of many other genes, with 886 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTCH1-associated genes across cancer lineages are TSPAN16, ASCL3, and ARFRP1. Each is linked with PTCH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTCH1-to-partner and partner-to-PTCH1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTCH1→partner) and Y-score (partner→PTCH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TSPAN16 →	+0.051	+4.104	<.001	<.001	3	2
OVARY	ASCL3 →	+0.138	+3.381	.003	.007	3	2
LARGE_INTESTINE	ARFRP1 →	-0.680	-2.371	<.001	<.001	3	2
LARGE_INTESTINE	CCNP →	+0.887	+3.169	.006	.006	3	2
LARGE_INTESTINE	MRPL34 →	+0.428	+2.458	.001	<.001	3	2
LARGE_INTESTINE	MMACHC →	+0.798	+2.458	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 886 associations by consensus.

Exploration

PTCH1 survival (RNA) · tumor vs normal (RNA) · all PTCH1 data types