PTCD3

Across TCGA patient cohorts, PTCD3 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTCD3-associated genes across cancer lineages are Caspase-7-cleavedD198, 14-3-3_beta, and EGFR_pY1068. Each is linked with PTCD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTCD3-to-partner and partner-to-PTCD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PTCD3-low versus PTCD3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTCD3→partner) and Y-score (partner→PTCD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.478	+1.341	.013	.043	3	2
UCEC	14-3-3_beta →	-0.099	-2.195	.002	.009	3	1
UCEC	EGFR_pY1068 →	-0.278	-2.502	<.001	.001	3	1
UCEC	eIF4E →	+0.190	+2.820	.005	.001	3	1
UCEC	ERK2 →	+0.140	+1.459	.024	.012	3	1
UCEC	FASN →	+0.313	+1.222	.014	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

Caspase-7-cleavedD198 by PTCD3 expression — UCEC

Explore this box plot interactively →