PTCD1

Across TCGA patient cohorts, PTCD1 mutation is significantly associated with the RNA expression of many other genes, with 1,615 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTCD1-associated genes across cancer lineages are RN7SL628P, SAAL1, and TMEM208. Each is linked with PTCD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTCD1-to-partner and partner-to-PTCD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL628P grouped by PTCD1-low versus PTCD1-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTCD1→partner) and Y-score (partner→PTCD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	RN7SL628P →	+0.097	+4.720	<.001	.005	3	2
UCEC	SAAL1 →	+0.353	+2.016	.008	.001	3	2
UCEC	TMEM208 →	+0.275	+1.617	.006	.003	3	2
UCEC	TIPIN →	+0.461	+2.136	<.001	<.001	3	2
UCEC	KIF22 →	+0.363	+1.847	.008	<.001	3	2
UCEC	SLC7A8 →	-0.815	-3.000	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,615 associations by consensus.

RN7SL628P by PTCD1 expression — LIHC

Explore this box plot interactively →