PTBP3

Across TCGA pan-cancer cohorts, PTBP3 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated PTBP3 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PTBP3 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PTBP3 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and UCEC show a favorable association.

CCRCC, UCEC, and COAD are the cancer types where PTBP3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	All	0.976	0.692	<.001	66	view →
UCEC	DFS	Median	All	0.965	0.767	.002	38	view →
COAD	DFS	Median	IV	0.432	0.944	.012	6	view →
LSCC	DFS	Median	II,III,IV	0.883	0.680	.021	5	view →
GBM	DFS	Quartile	All	0.269	0.593	.003	4	view →
PDAC	DFS	Tertile	IV	0.217	0.550	.024	3	view →
HNSC	DFS	Median	II,III,IV	0.983	0.909	.044	2	view →
LUAD	DFS	Tertile	All	0.942	0.795	.021	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

PTBP3–CCRCC (OS)

Open the CCRCC breakdown →