PTBP3

Across TCGA patient cohorts, PTBP3 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTBP3-associated genes across cancer lineages are mTOR_pS2448, PDCD4, and STAT3_pY705. Each is linked with PTBP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTBP3-to-partner and partner-to-PTBP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by PTBP3-low versus PTBP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTBP3→partner) and Y-score (partner→PTBP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.108	-1.861	.033	.049	3	2
UCEC	PDCD4 →	-0.409	-1.247	.010	.045	3	2
UCEC	STAT3_pY705 →	-0.531	-4.169	<.001	<.001	3	2
UCEC	VHL →	-0.748	-1.765	.001	.013	3	2
CESC	S6_pS235_S236 →	-0.587	-3.321	.013	.009	3	1
UCEC	14-3-3_beta →	-0.091	-2.088	.008	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

mTOR_pS2448 by PTBP3 expression — UCEC

Explore this box plot interactively →