PTBP2

Across TCGA patient cohorts, PTBP2 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTBP2-associated genes across cancer lineages are ERK2, INPP4B, and p27_pT198. Each is linked with PTBP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTBP2-to-partner and partner-to-PTBP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by PTBP2-low versus PTBP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTBP2→partner) and Y-score (partner→PTBP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.217	+2.115	.001	.016	3	2
UCEC	INPP4B →	-0.280	-2.222	.012	.009	3	2
UCEC	p27_pT198 →	+0.084	+1.736	.023	.007	3	2
UCEC	PDCD4 →	-0.451	-1.807	.005	.024	3	2
UCEC	ATM →	-0.678	-3.794	<.001	<.001	3	2
UCEC	Di-Ras3 →	-0.119	-2.571	.021	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

ERK2 by PTBP2 expression — UCEC

Explore this box plot interactively →