PTBP2

Across TCGA cell cohorts, PTBP2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,719 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PTBP2-associated GO terms across cancer lineages are Centrosome duplication, Double-strand break repair, and DNA recombination. Each is linked with PTBP2 in more than 16 cancer types. Because this analysis shows association rather than direction, both PTBP2-to-partner and partner-to-PTBP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Centrosome duplication grouped by PTBP2-low versus PTBP2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PTBP2→partner) and Y-score (partner→PTBP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Centrosome duplication →	+0.123	+0.923	<.001	.003	3	17
SOFT_TISSUE	Double-strand break repair →	+0.087	+1.432	<.001	<.001	3	16
SOFT_TISSUE	DNA recombination →	+0.089	+1.243	<.001	<.001	3	16
SOFT_TISSUE	Centrosome cycle →	+0.106	+1.287	<.001	<.001	3	16
OESOPHAGUS	Centriole replication →	+0.135	+0.899	<.001	.002	3	16
SOFT_TISSUE	Positive regulation of DNA repair →	+0.066	+1.070	.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,719 associations by consensus.

Centrosome duplication by PTBP2 expression — BONE

Explore this box plot interactively →