PTBP2

Across TCGA cell cohorts, PTBP2 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PTBP2-associated genes across cancer lineages are C16orf92, C2orf73, and TAS1R2. Each is linked with PTBP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTBP2-to-partner and partner-to-PTBP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C16orf92 grouped by PTBP2-low versus PTBP2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTBP2→partner) and Y-score (partner→PTBP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C16orf92 →	+0.196	+4.037	<.001	.004	3	1
BLOOD_Leukemia	C2orf73 →	+0.044	+4.450	.004	.001	3	1
BLOOD_Leukemia	TAS1R2 →	+0.009	+3.855	.004	.007	3	1
BLOOD_Leukemia	SIX6 →	+1.793	+3.769	<.001	.008	3	1
BLOOD_Leukemia	C8orf86 →	+0.039	+4.339	.001	.002	3	1
BLOOD_Leukemia	SMIM31 →	+0.017	+4.691	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

C16orf92 by PTBP2 expression — BLOOD_Leukemia

Explore this box plot interactively →