PTBP2

Across TCGA cell cohorts, PTBP2 mutation is significantly associated with the mutation status of many other genes, with 3,045 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTBP2-associated genes across cancer lineages are SLC7A4, USP48, and ELMO2. Each is linked with PTBP2 in more than 3 cancer types. Because this analysis shows association rather than direction, both PTBP2-to-partner and partner-to-PTBP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC7A4 grouped by PTBP2-low versus PTBP2-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTBP2→partner) and Y-score (partner→PTBP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SLC7A4 →	+4.977	+4.415	.007	.007	1	4
OVARY	USP48 →	+4.562	+5.217	<.001	<.001	1	3
OVARY	ELMO2 →	+4.977	+4.415	.007	.007	1	3
LARGE_INTESTINE	DHDH →	+4.672	+5.329	<.001	<.001	1	3
BLOOD_Leukemia	PBX4 →	+4.560	+4.309	.007	.007	1	3
LARGE_INTESTINE	MCM9 →	+2.865	+4.217	.007	.007	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,045 associations by consensus.

SLC7A4 by PTBP2 expression — OVARY

Explore this box plot interactively →