PTBP1

Across TCGA pan-cancer cohorts, PTBP1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PTBP1 data layer compared with 25 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PTBP1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PTBP1 expression acts as an unfavorable survival marker, although some lineages such as COAD and CCRCC show a favorable association.

COAD, HNSC, and CCRCC are the cancer types where PTBP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	1.000	0.888	.023	36	view →
HNSC	OS	Tertile	IV	0.482	0.884	<.001	9	view →
CCRCC	OS	Median	III,IV	0.901	0.679	.031	7	view →
LUAD	OS	Tertile	All	0.955	0.740	.040	3	view →
GBM	DFS	Median	All	0.475	0.271	.020	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PTBP1–COAD (DFS)

Open the COAD breakdown →