PSTPIP2

Across TCGA pan-cancer cohorts, PSTPIP2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PSTPIP2 data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PSTPIP2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PSTPIP2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LSCC show a favorable association.

COAD, UCEC, and LSCC are the cancer types where PSTPIP2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.872	1.000	.016	24	view →
UCEC	OS	Median	All	0.984	0.851	.013	20	view →
LSCC	DFS	Quartile	III,IV	0.843	0.210	.006	5	view →
GBM	OS	Tertile	All	0.392	0.639	.017	4	view →
PDAC	DFS	Median	IV	0.934	0.250	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PSTPIP2–COAD (DFS)

Open the COAD breakdown →