PSTPIP2

Across TCGA cell cohorts, PSTPIP2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,628 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PSTPIP2-associated GO terms across cancer lineages are Amyloid-beta clearance, Nuclear speck organization, and Regulation of autophagosome assembly. Each is linked with PSTPIP2 in more than 6 cancer types. Because this analysis shows association rather than direction, both PSTPIP2-to-partner and partner-to-PSTPIP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Amyloid-beta clearance grouped by PSTPIP2-low versus PSTPIP2-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PSTPIP2→partner) and Y-score (partner→PSTPIP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Amyloid-beta clearance →	+0.081	+1.293	.002	.001	3	7
UPPER_AERODIGESTIVE_TRACT	Nuclear speck organization →	-0.153	-0.890	.003	.006	2	7
SOFT_TISSUE	Regulation of autophagosome assembly →	+0.047	+1.074	.007	.005	3	6
STOMACH	Response to rapamycin →	+0.142	+1.688	.006	.002	3	6
OESOPHAGUS	Stress granule disassembly →	+0.084	+1.506	.003	.007	3	5
BLOOD_Leukemia	Formation of cytoplasmic translation initiation complex →	+0.086	+2.350	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,628 associations by consensus.

Amyloid-beta clearance by PSTPIP2 expression — LARGE_INTESTINE

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