PSTPIP1

Across TCGA patient cohorts, PSTPIP1 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSTPIP1-associated genes across cancer lineages are RAD51, p62 Lck ligand, and S6_pS240_S244. Each is linked with PSTPIP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSTPIP1-to-partner and partner-to-PSTPIP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAD51 grouped by PSTPIP1-low versus PSTPIP1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSTPIP1→partner) and Y-score (partner→PSTPIP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RAD51 →	+0.217	+2.815	.012	.036	3	2
UCEC	p62 Lck ligand →	+0.525	+3.710	<.001	<.001	3	2
UCEC	S6_pS240_S244 →	+0.528	+3.459	.001	.005	3	2
COAD	p27_pT157 →	+0.233	+2.815	.003	.036	3	1
UCEC	A-Raf_pS299 →	-0.139	-2.700	.004	.006	3	1
UCEC	Ku80 →	+0.225	+1.750	.021	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

RAD51 by PSTPIP1 expression — COAD

Explore this box plot interactively →