PSTPIP1

Across TCGA cell cohorts, PSTPIP1 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PSTPIP1-associated genes across cancer lineages are GUCA2A, SCGB2A1, and PFN3. Each is linked with PSTPIP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSTPIP1-to-partner and partner-to-PSTPIP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GUCA2A grouped by PSTPIP1-low versus PSTPIP1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSTPIP1→partner) and Y-score (partner→PSTPIP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GUCA2A →	+0.031	+4.384	<.001	.006	3	1
LARGE_INTESTINE	SCGB2A1 →	+0.619	+3.392	<.001	.006	3	1
LARGE_INTESTINE	PFN3 →	+0.093	+2.882	<.001	.005	3	1
LARGE_INTESTINE	SMIM33 →	+0.710	+3.648	<.001	.002	3	1
LUNG_NSCLC_LUAD	TAS2R7 →	+0.024	+4.734	<.001	.002	3	1
LUNG_NSCLC_LUAD	SPATA3 →	+0.009	+4.662	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

GUCA2A by PSTPIP1 expression — BLOOD_Leukemia

Explore this box plot interactively →