PSRC1

Across TCGA patient cohorts, PSRC1 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSRC1-associated genes across cancer lineages are MEK1, p62 Lck ligand, and p70-S6K. Each is linked with PSRC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSRC1-to-partner and partner-to-PSRC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by PSRC1-low versus PSRC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSRC1→partner) and Y-score (partner→PSRC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.541	+3.169	.007	.020	2	2
UCEC	p62 Lck ligand →	+0.601	+3.009	<.001	.019	3	1
UCEC	p70-S6K →	+0.254	+3.196	.016	.010	3	1
UCEC	PDK1_pS241 →	+0.337	+3.183	<.001	.010	3	1
UCEC	C-Raf_pS338 →	-0.090	-3.169	.044	.020	3	1
UCEC	PCNA →	+0.365	+3.169	.002	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

MEK1 by PSRC1 expression — UCEC

Explore this box plot interactively →