Across TCGA patient cohorts, PSPHP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,364 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible PSPHP1-associated GO terms across cancer lineages are L-serine biosynthetic process, tRNA 3'-end processing, and Mitochondrial cytochrome c oxidase assembly. Each is linked with PSPHP1 in more than 8 cancer types. Because this analysis shows association rather than direction, both PSPHP1-to-partner and partner-to-PSPHP1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PSPHP1→partner) and Y-score (partner→PSPHP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	L-serine biosynthetic process →	+0.055	+1.446	<.001	.002	3	9
STAD	tRNA 3'-end processing →	+0.028	+1.107	<.001	<.001	3	4
STAD	Mitochondrial cytochrome c oxidase assembly →	+0.031	+0.956	<.001	<.001	3	4
ESCA	Positive regulation of telomerase RNA localization to Cajal body →	+0.044	+1.945	<.001	<.001	2	5
ESCA	Obsolete C-5 methylation of cytosine →	+0.083	+2.471	<.001	<.001	3	3
ESCA	Regulation of metaphase plate congression →	+0.039	+1.372	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,364 associations by consensus.

Exploration

PSPHP1 survival (RNA) · tumor vs normal (RNA) · all PSPHP1 data types