PSPH

Across TCGA pan-cancer cohorts, PSPH mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of PSPH’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where PSPH mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types PSPH is over-expressed in tumor, although a few such as PDAC and CCRCC show the opposite, repressed pattern.

LSCC, LUAD, and HNSC are the cancer types where PSPH tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PSPH mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	All	+0.779	<.001	8	view →
LUAD	Male	III,IV	+0.592	<.001	8	view →
HNSC	All	All	+0.259	.001	8	view →
PDAC	All	All	−0.290	.001	6	view →
COAD	All	II,III,IV	+0.216	<.001	6	view →
CCRCC	All	All	−0.117	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

PSPH–LSCC

Open the LSCC breakdown →