PSPC1

Across TCGA pan-cancer cohorts, PSPC1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PSPC1 data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher PSPC1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PSPC1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, HNSC, and CCRCC are the cancer types where PSPC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	All	0.705	0.430	<.001	77	view →
HNSC	DFS	Median	All	0.692	0.860	.002	37	view →
CCRCC	DFS	Tertile	II,III,IV	0.972	0.140	.006	25	view →
LSCC	OS	Median	II,III,IV	1.000	0.885	.021	8	view →
UCEC	OS	Tertile	All	1.000	0.872	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PSPC1–PDAC (OS)

Open the PDAC breakdown →