PSPC1

Across TCGA patient cohorts, PSPC1 mutation is significantly associated with the RNA expression of many other genes, with 925 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSPC1-associated genes across cancer lineages are RPS10-NUDT3, BPY2DP, and TRAJ37. Each is linked with PSPC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSPC1-to-partner and partner-to-PSPC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS10-NUDT3 grouped by PSPC1-low versus PSPC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSPC1→partner) and Y-score (partner→PSPC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPS10-NUDT3 →	+0.212	+2.102	.001	.004	3	2
COAD	BPY2DP →	+0.194	+5.409	<.001	.001	3	2
UCEC	TRAJ37 →	+0.841	+2.380	<.001	<.001	3	2
LUAD	CRIP1P3 →	+0.220	+4.754	<.001	.003	3	2
LUAD	SNX18P8 →	+0.054	+5.087	<.001	.004	3	2
CESC	MIR3194 →	+0.746	+5.569	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 925 associations by consensus.

RPS10-NUDT3 by PSPC1 expression — UCEC

Explore this box plot interactively →