PSPC1

Across TCGA patient cohorts, PSPC1 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSPC1-associated genes across cancer lineages are EGFR, eIF4E, and FOXO3a. Each is linked with PSPC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSPC1-to-partner and partner-to-PSPC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by PSPC1-low versus PSPC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSPC1→partner) and Y-score (partner→PSPC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.189	-2.000	.002	.030	3	1
UCEC	eIF4E →	+0.246	+2.807	.002	.003	3	1
UCEC	FOXO3a →	+0.141	+2.598	<.001	<.001	3	1
UCEC	MEK1 →	+0.432	+3.584	.002	.002	3	1
UCEC	p62 Lck ligand →	+0.329	+2.584	.008	.001	3	1
UCEC	PCNA →	+0.244	+2.321	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

EGFR by PSPC1 expression — UCEC

Explore this box plot interactively →